Nanotechnology based assays for validating protein biomarkers
Overall costs of the disease are 6 billion annually.
The research projects at Biomedical Microdevices and Nanotechnology Lab focuses on multi scale integration across organic and inorganic interfaces.Modelling of the data showed that the new prostate biomarkers and PSA in combination were better than PSA alone in identifying prostate cancer, improved the prediction of high and low risk disease, and improved prediction of cancer versus benign prostate hyperplasia.Prostate cancer; Prostate specific antigen; Biomarker; FLNA; FLNB; KRT19 Abbreviations: PSA: Prostate Specific Antigen; GS: Gleason Score; FLNA: Filamin-A; FLNB: Filamin-B; KRT19: Keratin-19; IPMRM: Immunoprecipitation Multiple Reaction Monitoring) Prostate cancer (Pr Ca) is a leading cause of cancer deaths in American men [1,2].Due to their exceptional structural and functional properties that are not available from bulk materials or discrete molecules, nanotechnology is opening new horizons for low cost, rapid, highly sensitive, and highly specific detection of circulating cancer markers. Xiaohua Huang is an associate professor of chemistry and biomedical engineering at The University of Memphis, USA. She has published 50 peer- reviewed journal articles and 7 book chapters. Huang's group include: (1) Shape-controlled synthesis and properties of magnetic-plasmonic core-shell nanoparticles; (2) Single particle optical imaging and spectroscopy; (3) Isolation, detection, and analysis of circulating tumor cells; and (4) Detection and analysis of exosomes and microvesicles. Gold nanoparticles have emerged as a unique nanoplatform for circulating biomarker detection owning to their advantages of easy synthesis, facile surface chemistry, excellent biocompatibility, and remarkable structure and environment sensitive optical properties. Simultaneous detection of nucleic acid and protein using gold nanoparticles and lateral flow device. Ryan O'Connor received his bachelor's degree in chemistry from Xavier University in 2013.